Genetics of Food Allergy and Intolerance

Posted on by Randall J. Lopez

White blood mobile styles decided genetically and detailed as HLA DQ and DR genes had been recognized with an expanded hazard of pollen, dust, latex, and meals hypersensitive reactions. The fascinating a part of this tale is that there is an advantage to knowing your HLA DR and DQ kind while evaluating your hazard for pollen hypersensitive reactions and their associated food allergic reactions or pass reactions.

Genetics of Food Reactions and Allergies

As I give an explanation for in extra element in my articles on the genetics of gluten sensitivity, all of us have proteins on the surface of our cells that are genetically decided. These patterns are without difficulty detectable by using testing cells from blood or from the mouth acquired by means of a Q-tip kind swab. Specific styles were associated with the improved threat for autoimmune situations, gluten sensitivity, and celiac disorder.

HLA DQ Genetics and Celiac or Gluten Sensitivity

HLA DQ2 is found in greater than 90% of human beings who have celiac ailment at the same time as HLADQ8 is found in a maximum of the rest, though no longer everybody with celiac has been determined to have DQ2 and/or DQ8.

DQ and DR Genetic Patterns Associated with Food and Pollen Allergies or Sensitivities?

Now it seems positive DQ or DR styles are associated with meals and pollen hypersensitive reactions as properly. As the Food Doc, I preserve to search the literature for greater data approximately genetic hyperlinks to food hypersensitive reaction and intolerance. My seek has led me to more than one exciting articles inside the uncommon place of oral allergy syndrome (OAS). The dating among seasonal and perennial nasal allergies and meals allergies is surely properly installed however not typically regarded by means of most doctors or patients. It appears that some of us need to keep away from consuming sure foods if we’ve got hay fever or allergic reactions, especially at some point of the hay fever season. This trouble also appears to be inherited.

Research Documents Genetic Association With Certain Food and Pollen Allergies

Boehncke, et al. From the University of Frankfurt mentioned in 1998 that positive white blood cell kinds acknowledged HLA class II genotypes or HLA DQ and DR genetic patterns had been observed more frequently in humans with sure pollen associated food allergic reactions. HLA-DQB1*0301 is found in greater human beings with grass pollen hypersensitive reaction. Those with HLA-DRB1*08, an inherited white blood cellular protein pattern related with a grass pollen allergy, have six instances the expanded chance of peanut hypersensitive reaction. Those who have inherited the HLA-DRB1*12 white bloodmobile sample are thirteen instances better at threat for carrot hypersensitivity.

Tree Pollen Allergy to Birch Tree Pollen Appears to be Worst

Birch pollen associated hazel nut hypersensitivity is connected to HLA-DRB1*01, DQA1*0101, and DQB1*0501. Hazelnut, almond, walnut, and apple are the maximum commonplace meals hypersensitive reactions associated with birch tree pollen. Allergies to the one’s foods are usually related to birch tree pollen in other research.

Weed Allergies Also Associated With Food Reactions

In 2004, Wang et al. From China published that the inherited white bloodmobile kind DQA1*0302 is determined in more people with Artemisia pollen-caused allergic rhinitis, hay fever due to Mugwort or Sagebrush weeds. Mugwort allergy is related to numerous food allergies inclusive of apple, celery, hazelnut, pistachio, lettuce, almond, peanut, and carrots.

Where to Get Genetic Testing

There are three industrial labs that I am aware of that offer full HLA DQ typing. They are Quest Laboratories, The Laboratory at Bonfils in Denver, and Enterolab. Bonfils runs the Enterolab genetic assessments. Enterolab offers the check run on samples of cells acquired from a Q-tip swab of the mouth. The take a look at can be acquired immediately from Enterolab without a physician’s order although it isn’t always protected with the aid of coverage. It, however, is very affordable from a genetic checking out standpoint at $149. Bonfils additionally does the DQ typing on cells received from blood samples sent to them from other labs.

The Future of Genetic Testing in Pollen and Food Allergies

In the destiny such checking out should be very helpful in evaluating suspected meals allergies, intolerance and pollen allergies. In the period in-between those folks inquisitive about this thrilling tale anxiously wait for more studies findings in this thrilling vicinity. Dr. Fine, the founder of Enterolab, has previously posted the HLA DQ styles associated with microscopic colitis. He has discovered that microscopic changes in the colon or huge intestine are similar if no longer identical to what’s seen inside the small gut in celiac ailment. Several articles now report that a gluten loose food regimen works in many humans with microscopic, lymphocytic and collagenous colitis. It additionally enables many with Crohn’s sickness and ulcerative colitis.

A finding of intraepithelial lymphocytosis in the distal small gut (terminal ileum) is associated with an improved prevalence of celiac sickness within the proximal small gut. Now, including to the intrigue, are those articles linking positive inherited white bloodmobile protein gene styles to pollen hypersensitivity and food allergy cross-reactions which are properly identified but hardly ever pursued clinically. Oral Allergy Syndrome (OAS), additionally known as the “burning mouth syndrome”, takes place in many human beings but frequently is going undiagnosed. Symptoms encompass burning, painful and/or itching sensation of mouth or throat with or without swelling that occurs nearly immediately after eating sure ingredients. The meals inflicting those reactions are usually associated with pollen, latex or dust allergic reactions.

Unusual Association of Pollen Allergies and Mouth Burning or Food Reactions

This unusual affiliation of the tree, grass, and weed pollens, latex and residence dust mite-hypersensitive reactions to meals reactions, even though nicely documented inside the medical literature, is not commonly diagnosed by docs or patients. The OAS literature includes numerous reports of meals hypersensitivity or intolerance reactions which might be associated with specific pollen, dust, mold or latex allergies. One of the quality examples is a ragweed pollen hypersensitive reaction. It is related to a higher danger of meals hypersensitivity or intolerance to only a few meals. These consist of meals within the gourd own family (cucumbers and melons) and bananas. On different the hand, Birch tree pollen hypersensitive reaction is associated with sensitivity to many foods. The listing consists of those meals within the Rosacea circle of relatives (apples, pears), tree nut circle of relatives (hazelnut, almond, walnut), potatoes, and carrots. Reactions encompass conventional hypersensitive reactions consisting of skin rashes (atopic dermatitis, hives), wheezing (allergies), runny nose (allergic rhinitis), in addition to the burning mouth OAS signs and symptoms and other food intolerance signs.